tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate

Base Information

Chemical Name:tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate
CAS No.:1357158-04-3
Molecular Formula:C₂₂H₃₂ClN₃O₃
Molecular Weight:421.967
Hs Code.:

Synonyms:tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate

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Chemical Property of tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate

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Technology Process of tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate

There total 6 articles about tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1357157-93-7
(3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methanol

: 105-39-5
chloroacetic acid ethyl ester

: 75-65-0
tert-butyl alcohol

: 1357158-04-3
tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate

Guidance literature:: tert-butyl alcohol; With potassium; Inert atmosphere;

(3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methanol; In tert-butyl alcohol; for 0.166667h; Inert atmosphere;

chloroacetic acid ethyl ester; In tert-butyl alcohol; for 3h; Inert atmosphere; Reflux;
DOI:10.1002/cjoc.201180354

Reference yield:

: 938182-43-5,595610-40-5
5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

: 1357158-04-3
tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 3.17 h / 20 °C / Reflux

2.1: potassium carbonate; potassium iodide / acetonitrile / 5.17 h / 20 °C / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

4.1: potassium / Inert atmosphere

4.2: 0.17 h / Inert atmosphere

4.3: 3 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; potassium; potassium carbonate; potassium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/cjoc.201180354

Reference yield:

: 1101861-37-3
ethyl 3-(4-chlorophenyl)-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate

: 1357158-04-3
tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 5.17 h / 20 °C / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

3.1: potassium / Inert atmosphere

3.2: 0.17 h / Inert atmosphere

3.3: 3 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; potassium; potassium carbonate; potassium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/cjoc.201180354