Technology Process of [4-(methyloxy)phenyl][(1S,2S)-2-(4-methylphenyl)-1-nitrocyclopropyl]methanone
There total 4 articles about [4-(methyloxy)phenyl][(1S,2S)-2-(4-methylphenyl)-1-nitrocyclopropyl]methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; tetrakis[(S)-(N-tetrachlorophthalimido)-tert-lucinato]dirhodium(II);
In
diethyl ether;
at -45 ℃;
for 16h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja201237j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
1.2: 16 h / Inert atmosphere; Reflux
2.1: pyridine; triflic azide / hexane; acetonitrile / 16 h / 0 - 20 °C / Inert atmosphere
3.1: dmap; tetrakis[(S)-(N-tetrachlorophthalimido)-tert-lucinato]dirhodium(II) / diethyl ether / 16 h / -45 °C / Inert atmosphere
With
pyridine; dmap; tetrakis[(S)-(N-tetrachlorophthalimido)-tert-lucinato]dirhodium(II); triflic azide; sodium hydride;
In
tetrahydrofuran; diethyl ether; hexane; acetonitrile; mineral oil;
DOI:10.1021/ja201237j
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine; triflic azide / hexane; acetonitrile / 16 h / 0 - 20 °C / Inert atmosphere
2: dmap; tetrakis[(S)-(N-tetrachlorophthalimido)-tert-lucinato]dirhodium(II) / diethyl ether / 16 h / -45 °C / Inert atmosphere
With
pyridine; dmap; tetrakis[(S)-(N-tetrachlorophthalimido)-tert-lucinato]dirhodium(II); triflic azide;
In
diethyl ether; hexane; acetonitrile;
DOI:10.1021/ja201237j