1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate

Base Information

Chemical Name:1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate
CAS No.:1020202-66-7
Molecular Formula:C₂₅H₃₅N₃O₃Si
Molecular Weight:453.657
Hs Code.:

Synonyms:1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate

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Chemical Property of 1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate

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Technology Process of 1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate

There total 1 articles about 1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1020202-65-6
1-(2-azido-phenyl)-prop-2-ynyl acetate

: 1020202-64-5
tert-butyl-(3-iodo-6,6-dimethyl-cyclohex-2-enyloxy)-dimethylsilane

: 1020202-66-7
1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; for 16h; Inert atmosphere;
DOI:10.1021/ol800429j

Reference yield: 95.0%

: 1020202-66-7
1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate

: 13170-43-9
(trimethylsilyl)methylmagnesium chloride

: 1161422-46-3
1-azido-2-{3-[3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethylcyclohex-1-enyl]-4-trimethylsilanyl-buta-1,2-dienyl}-benzene

Guidance literature:: (trimethylsilyl)methylmagnesium chloride; With copper(l) iodide; lithium bromide; In tetrahydrofuran; diethyl ether; for 0.5h; Cooling with ice;

1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate; In tetrahydrofuran; diethyl ether; for 0.5h; Cooling with ice;
DOI:10.1021/jo900659w

Reference yield: 92.0%

: 1020202-66-7
1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate

: 75-16-1
methylmagnesium bromide

: 1020202-67-8
{3-[3-(2-azido-phenyl)-1-methyl-propa-1,2-dienyl]-6,6-dimethyl-cyclohex-2-enyloxy}-tert-butyl-dimethyl-silane

Guidance literature:: methylmagnesium bromide; With copper(l) iodide; lithium bromide; In tetrahydrofuran; diethyl ether; for 0.5h; Cooling with ice;

1-(2-azido-phenyl)-3-[3-(tert-butyldimethylsilanyloxy)-4,4-dimethyl-cyclohex-1-enyl]-prop-2-ynyl acetate; In tetrahydrofuran; diethyl ether; for 0.5h; Cooling with ice;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; Cooling with ice;
DOI:10.1021/ol800429j