1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclopentanol

Base Information

• Chemical Name: 1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclopentanol
• CAS No.: 757249-31-3
• Molecular Formula: C₁₇H₂₃NO₃S
• Molecular Weight: 321.441
• Mol file: 757249-31-3.mol

Synonyms:1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclopentanol

Chemical Property of 1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclopentanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclopentanol

There total 1 articles about 1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

cyclobutanone (1191-95-3) + 1-(toluene-4-sulfonyl)-6-trimethylstannyl-1,2,3,4-tetrahydropyridine → 1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclopentanol (757249-31-3) + 1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine (81097-36-1)

Guidance literature:

1-(toluene-4-sulfonyl)-6-trimethylstannyl-1,2,3,4-tetrahydropyridine; With methyllithium; In diethyl ether; at 0 ℃; for 0.166667h;

With magnesium bromide; In diethyl ether; at -78 ℃; for 0.5h;

cyclobutanone; In diethyl ether; at -100 - 20 ℃;

DOI:10.1021/jo049356+

Reference yield: 89.0%

1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclopentanol (757249-31-3) + allyl-trimethyl-silane (762-72-1) → 3-allyl-2-cyclopentylidene-1-(toluene-4-sulfonyl)-piperidine (757249-57-3)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 0.75h;

DOI:10.1021/jo049356+

Reference yield: 68.0%

1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclopentanol (757249-31-3) + trimethylsilyl trifluoromethanesulfonate (27607-77-8) → 6-cyclopent-1'-enyl-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine + 1-(toluene-4-sulfonyl)-6-(1-trimethylsilyloxycyclopentyl)-1,2,3,4-tetrahydropyridine (353248-29-0)

Guidance literature:

With 2,6-dimethylpyridine; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1021/jo049356+

upstream raw materials:

cyclobutanone

Downstream raw materials:

1-(toluene-4-sulfonyl)-6-(1-trimethylsilyloxycyclopentyl)-1,2,3,4-tetrahydropyridine

3-allyl-2-cyclopentylidene-1-(toluene-4-sulfonyl)-piperidine