(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-dimethylpiperazine

Base Information

Chemical Name:(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-dimethylpiperazine
CAS No.:956467-57-5
Molecular Formula:C₂₂H₂₈N₂O₈S₂
Molecular Weight:512.605
Hs Code.:

Synonyms:(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-dimethylpiperazine

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Chemical Property of (2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-dimethylpiperazine

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Technology Process of (2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-dimethylpiperazine

There total 5 articles about (2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-dimethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956468-02-3
(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethylpiperazine hydrochloride

: 63758-12-3
6-chlorosulfonyl-1,4-benzodioxane

: 956467-57-5
(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-dimethylpiperazine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 956467-99-5
(3S,6S)-4-benzyl-3,6-dimethylpiperazine-2,5-dione

: 956467-57-5
(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-dimethylpiperazine

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 7 h / Heating / reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: hydrogenchloride; water; hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With hydrogenchloride; borane-THF; water; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 956467-98-4
methyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-alanyl-N-(phenylmethyl)-L-alaninate

: 956467-57-5
(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-dimethylpiperazine

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2: borane-THF / tetrahydrofuran / 7 h / Heating / reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: hydrogenchloride; water; hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With hydrogenchloride; borane-THF; water; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;