7-methoxy-naphthalene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(1H-pyrazol-3-ylmethyl)-amide

Base Information

• Chemical Name: 7-methoxy-naphthalene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(1H-pyrazol-3-ylmethyl)-amide
• CAS No.: 247030-97-3
• Molecular Formula: C₂₇H₂₅N₅O₄S
• Molecular Weight: 515.593
• Mol file: 247030-97-3.mol

Synonyms:7-methoxy-naphthalene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(1H-pyrazol-3-ylmethyl)-amide

Chemical Property of 7-methoxy-naphthalene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(1H-pyrazol-3-ylmethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-methoxy-naphthalene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(1H-pyrazol-3-ylmethyl)-amide

There total 7 articles about 7-methoxy-naphthalene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(1H-pyrazol-3-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide (186551-71-3) → 7-methoxy-naphthalene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(1H-pyrazol-3-ylmethyl)-amide (247030-97-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4h;

DOI:10.1021/jm990040h

Reference yield:

7-hydroxynaphthalene-2-sulfonic acid sodium salt (135-55-7) → 7-methoxy-naphthalene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(1H-pyrazol-3-ylmethyl)-amide (247030-97-3)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaOH / ethanol / 16 h / 20 °C

2: 3.80 g / POCl₃; PCl₅ / 4 h / 120 °C

3: Et₃N / CH₂Cl₂ / 2 h

4: K₂CO₃ / acetone / 48 h

5: HCl / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; sodium hydroxide; phosphorus pentachloride; potassium carbonate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; ethyl acetate; acetone; 1: Methylation / 2: Chlorination / 3: Condensation / 4: Alkylation / 5: acidolysis;

DOI:10.1021/jm990040h

Reference yield:

7-Methoxy-2-naphthalenesulfonyl chloride (56875-60-6) → 7-methoxy-naphthalene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(1H-pyrazol-3-ylmethyl)-amide (247030-97-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: K₂CO₃ / acetone / 48 h

3: HCl / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; In dichloromethane; ethyl acetate; acetone; 1: Condensation / 2: Alkylation / 3: acidolysis;

DOI:10.1021/jm990040h

upstream raw materials:

7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](N-tert-butyloxycarbonylpyrazol-3-ylmethyl)amide

7-hydroxynaphthalene-2-sulfonic acid sodium salt

7-Methoxy-2-naphthalenesulfonyl chloride

[1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester