N-(2,4-difluorophenyl)-2,2-dimethylpropanamide

Base Information

Chemical Name:N-(2,4-difluorophenyl)-2,2-dimethylpropanamide
CAS No.:124704-01-4
Molecular Formula:C₁₁H₁₃F₂NO
Molecular Weight:213.227
Hs Code.:2921420090
DSSTox Substance ID:DTXSID40378972
Nikkaji Number:J3.155.775E
Wikidata:Q82168593
Mol file:124704-01-4.mol

Synonyms:124704-01-4;2,4-Difluoro-N-(2,2-dimethylpropanoyl)aniline;N-(2,4-difluorophenyl)-2,2-dimethylpropanamide;N-(2,4-difluorophenyl)pivalamide;JHICC03015;SCHEMBL14254877;DTXSID40378972;JHEVHMUNERDXND-UHFFFAOYSA-N;MFCD00751599;AKOS003854029;AB07018;N-(2,4-Difluorophenyl)-2,2-dimethylpropionamide

Suppliers and Price of N-(2,4-difluorophenyl)-2,2-dimethylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,4-DIFLUORO-N-(2,2-DIMETHYLPROPANOYL)ANILINE 95.00%
5G
$ 933.45

American Custom Chemicals Corporation
2,4-DIFLUORO-N-(2,2-DIMETHYLPROPANOYL)ANILINE 95.00%
1G
$ 651.54

Total 6 raw suppliers

Chemical Property of N-(2,4-difluorophenyl)-2,2-dimethylpropanamide

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:213.09652036
Heavy Atom Count:15
Complexity:237

Purity/Quality:

98%Min ^*data from raw suppliers

2,4-DIFLUORO-N-(2,2-DIMETHYLPROPANOYL)ANILINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)C(=O)NC1=C(C=C(C=C1)F)F

Technology Process of N-(2,4-difluorophenyl)-2,2-dimethylpropanamide

There total 1 articles about N-(2,4-difluorophenyl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 88288-07-7
N-(2-fluorophenyl)pivalamide

: 124704-01-4
N-(2,4-difluorophenyl)pivalamide

Guidance literature:: With bis(tertbutylcarbonyloxy)iodobenzene; pyridine hydrogenfluoride; In dichloromethane; at 20 ℃; for 24h; regioselective reaction;
DOI:10.1021/jo302099d

Reference yield: 50.7%

: 124704-01-4
N-(2,4-difluorophenyl)pivalamide

: 130345-50-5
quinoxaline-6-carbaldehyde

: 1428663-52-8
N-(2,4-difluoro-3-(hydroxy(quinoxalin-6-yl)methyl)phenyl)pivalamide

Guidance literature:: N-(2,4-difluorophenyl)pivalamide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

quinoxaline-6-carbaldehyde; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

: 124704-01-4
N-(2,4-difluorophenyl)pivalamide

: 1428663-50-6
(3-amino-2,6-difluorophenyl)(quinoxalin-6-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: manganese(IV) oxide / dichloromethane / 50 °C

3.1: hydrogenchloride; water / acetic acid / 4 h / 110 °C

With hydrogenchloride; manganese(IV) oxide; n-butyllithium; water; In tetrahydrofuran; dichloromethane; acetic acid;