(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide
CAS No.:939039-32-4
Molecular Formula:C₂₄H₂₃ClF₄N₂OS
Molecular Weight:498.972
Hs Code.:

Synonyms:(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

There total 9 articles about (R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 939426-99-0
(R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

: 6921-34-2
benzylmagnesium chloride

: 939039-32-4
(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: (R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide; With boron trifluoride diethyl etherate; In tert-butyl methyl ether; at -78 ℃; for 0.0833333h;

benzylmagnesium chloride; In diethyl ether; tert-butyl methyl ether; for 0.666667h;

With water; In diethyl ether; tert-butyl methyl ether;

Reference yield: 72.0%

: 939039-30-2
C₁₇H₁₅ClF₄N₂OS

: 6921-34-2
benzylmagnesium chloride

: 939039-32-4
(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: C₁₇H₁₅ClF₄N₂OS; With boron trifluoride diethyl etherate; In tert-butyl methyl ether; at -78 ℃; for 0.0833333h; Inert atmosphere;

benzylmagnesium chloride; In diethyl ether; tert-butyl methyl ether; at -78 ℃; for 0.666667h; Inert atmosphere;

With water; sodium chloride; In diethyl ether; tert-butyl methyl ether; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2012.01.050

Reference yield:

: 89809-64-3
2-cyano-5-chloropyridine

: 939039-32-4
(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 14 h / 75 °C

3.1: boron trifluoride diethyl etherate / tert-butyl methyl ether / 0.08 h / -78 °C / Inert atmosphere

3.2: 0.67 h / -78 °C / Inert atmosphere

3.3: Inert atmosphere

With titanium(IV) tetraethanolate; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; tert-butyl methyl ether; 3.2: Grignard addition;
DOI:10.1016/j.tet.2012.01.050