(R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide
CAS No.:939426-99-0
Molecular Formula:C₁₇H₁₅ClF₄N₂OS
Molecular Weight:406.832
Hs Code.:

Synonyms:(R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

There total 1 articles about (R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 939039-29-9
(5-chloropyridin-2-yl)(3-fluoro-5-(trifluoromethyl)phenyl)methanone

: 196929-78-9
(R)-2-methylpropane-2-sulfinamide

: 939426-99-0
(R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

Guidance literature:: With titanium(IV) tetraethanolate; In tetrahydrofuran; at 20 - 75 ℃; for 14h;

Reference yield: 77.0%

: 939426-99-0
(R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

: 105-45-3
acetoacetic acid methyl ester

: 939039-35-7
(S)-methyl 3-(5-chloropyridin-2-yl)-3-((R)-1,1-dimethylethylsulfinamino)-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

: (R)-methyl 3-(5-chloropyridin-2-yl)-3-((R)-1,1-dimethylethylsulfinamino)-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: acetoacetic acid methyl ester; With lithium diisopropyl amide; In diethyl ether; cyclohexane; at -78 ℃; for 0.5h;

(R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide; With triisopropoxytitanium(IV) chloride; In hexanes; diethyl ether; cyclohexane; at -78 - 20 ℃; for 1.5h;

Reference yield: 72.0%

: 939426-99-0
(R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

: 6921-34-2
benzylmagnesium chloride

: 939039-32-4
(R)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: (R)-N-((5-chloropyridin-2-yl)(6-(trifluoromethyl)pyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide; With boron trifluoride diethyl etherate; In tert-butyl methyl ether; at -78 ℃; for 0.0833333h;

benzylmagnesium chloride; In diethyl ether; tert-butyl methyl ether; for 0.666667h;

With water; In diethyl ether; tert-butyl methyl ether;