(2-fluoro-3-iodophenyl)methanol

Base Information

• Chemical Name: (2-fluoro-3-iodophenyl)methanol
• CAS No.: 307975-02-6
• Molecular Formula: C₇H₆FIO
• Molecular Weight: 252.027
• Hs Code.: 2906290090
• Mol file: 307975-02-6.mol

Synonyms:(2-fluoro-3-iodo-phenyl)-methanol

Chemical Property of (2-fluoro-3-iodophenyl)methanol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-3-iodobenzylalcohol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-fluoro-3-iodophenyl)methanol

There total 5 articles about (2-fluoro-3-iodophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-fluoro-3-iodobenzoic acid (447464-03-1) → (2-fluoro-3-iodo-phenyl)-methanol (307975-02-6)

Guidance literature:

2-fluoro-3-iodobenzoic acid; With Trimethyl borate; In tetrahydrofuran; at 0 ℃;

With borane dimethyl sulfide complex; In tetrahydrofuran; at 0 - 20 ℃;

With methanol; In tetrahydrofuran;

Reference yield:

2-fluorobenzonitrile (394-47-8) → (2-fluoro-3-iodo-phenyl)-methanol (307975-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,2,6,6-tetramethylpiperidinyl-lithium; iodine / tetrahydrofuran / -78 - 20 °C

2: sulfuric acid / 1,4-dioxane / 115 °C

3: Trimethyl borate; dimethyl sulfide borane / tetrahydrofuran / 0 - 20 °C

With Trimethyl borate; sulfuric acid; 2,2,6,6-tetramethylpiperidinyl-lithium; iodine; dimethyl sulfide borane; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1016/j.bmcl.2011.09.006

Reference yield:

2-fluoro-3-iodobenzonitrile (211943-27-0) → (2-fluoro-3-iodo-phenyl)-methanol (307975-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 1,4-dioxane / 115 °C

2: Trimethyl borate; dimethyl sulfide borane / tetrahydrofuran / 0 - 20 °C

With Trimethyl borate; sulfuric acid; dimethyl sulfide borane; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1016/j.bmcl.2011.09.006

upstream raw materials:

2-fluoro-3-iodobenzoic acid

1-Fluoro-2-iodobenzene

2-fluoro-3-iodobenzonitrile

2-fluorobenzonitrile

Downstream raw materials:

1-bromomethyl-2-fluoro-3-iodo-benzene

2-fluoro-3-iodobenzaldehyde

2-fluoro-3-iodobenzaldehyde oxime

C₇H₄ClFINO

Refernces

• 1、 -. "2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS". Page/Page column 60; 61. . Retrieved 2013/05/23.
• 2、 -. "New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors". Page/Page column 32-33. . Retrieved 2009/12/04.