(2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone

Base Information

• Chemical Name: (2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone
• CAS No.: 171016-57-2
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.282

Synonyms:(2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone

Chemical Property of (2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone

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Technology Process of (2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone

There total 1 articles about (2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-methoxysalicylic acid (2612-02-4) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → (2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone (171016-57-2)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/0040-4039(95)01592-6

Reference yield: 57.0%

p-toluenesulfonyl chloride (98-59-9) + (2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone (171016-57-2) → Toluene-4-sulfonic acid (S)-1-(2-hydroxy-5-methoxy-benzoyl)-pyrrolidin-2-ylmethyl ester (171016-58-3)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1016/0040-4039(95)01592-6

Reference yield: 49.0%

(2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone (171016-57-2) → Toluene-4-sulfonic acid (S)-1-(2-hydroxy-5-methoxy-benzoyl)-pyrrolidin-2-ylmethyl ester (171016-58-3) + ((S)-2-Chloromethyl-pyrrolidin-1-yl)-(2-hydroxy-5-methoxy-phenyl)-methanone + Toluene-4-sulfonic acid 2-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-4-methoxy-phenyl ester

Guidance literature:

With pyridine; p-toluenesulfonyl chloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(98)83036-6

upstream raw materials:

5-methoxysalicylic acid

(S)-1-Pyrrolidin-2-yl-methanol

Downstream raw materials:

Toluene-4-sulfonic acid (S)-1-(2-hydroxy-5-methoxy-benzoyl)-pyrrolidin-2-ylmethyl ester

Toluene-4-sulfonic acid (S)-1-(5-methoxy-2-trifluoromethanesulfonyloxy-benzoyl)-pyrrolidin-2-ylmethyl ester

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