tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Name:tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate
CAS No.:1373278-13-7
Molecular Formula:C₂₄H₂₅FN₂O₄
Molecular Weight:424.472
Hs Code.:

Synonyms:tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Property of tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Technology Process of tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

There total 7 articles about tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1373278-12-6
tert-butyl 5-(3-(4-fluorophenyl)-7-(methoxy(methyl)carbamoyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

: 1373278-13-7
tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

: 917889-25-9
3-(4-fluoro-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester

: 1373278-13-7
tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

2.2: 16 h / 60 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; diisobutylaluminium hydride; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1373278-10-4
methyl 2-(5-tert-butoxy-5-oxopentyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

: 1373278-13-7
tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;