5-Hydroxy-4,5-dioxopentanoate

Base Information

• Chemical Name: 5-Hydroxy-4,5-dioxopentanoate
• CAS No.: 144509-68-2
• Molecular Formula: C₅H₅O₅
• Molecular Weight: 145.092
• Nikkaji Number: J662.779J
• Mol file: 144509-68-2.mol

Synonyms:

Chemical Property of 5-Hydroxy-4,5-dioxopentanoate

Chemical Property:

• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 145.01369826
• Heavy Atom Count: 10
• Complexity: 165

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(CC(=O)[O-])C(=O)C(=O)O

Technology Process of 5-Hydroxy-4,5-dioxopentanoate

There total 1 articles about 5-Hydroxy-4,5-dioxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

NAD (53-84-9,66844-06-2) + monosodium L-glutamate (142-47-2) → α-ketoglutarate (144509-68-2) + NADH (58-68-4,443892-10-2)

Guidance literature:

With potassium phosphate buffer; at 37 ℃; pH=7.7; Enzyme kinetics;

DOI:10.1271/bbb.69.1861

Reference yield:

α-ketoglutarate (144509-68-2) + NADH (58-68-4,443892-10-2) → NAD (53-84-9,66844-06-2) + glutamate

Guidance literature:

With ammonium chloride; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1271/bbb.69.1802

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + nicotinamide adenine dinucleotide (865-05-4) + α-ketoglutarate (144509-68-2) + folate (59-30-3) → L-phosphoserine (407-41-0,7331-08-0) + NADH (58-68-4,443892-10-2)

Guidance literature:

With Phosphoserine aminotransferase; phosphoserine phosphatase; E_. coli D-3-phosphoglycerate dehydrogenase; magnesium chloride; In aq. buffer; for 0.166667h;

DOI:10.1021/acs.biochem.8b00074

upstream raw materials:

NAD

monosodium L-glutamate

Downstream raw materials:

L-glutamic acid

NAD

L-phosphoserine

NADH