(3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Base Information

Chemical Name:(3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
CAS No.:1353050-22-2
Molecular Formula:C₃₉H₄₅FN₄O₁₂
Molecular Weight:780.804
Hs Code.:

(3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Synonyms:(3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

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Chemical Property of (3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

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Technology Process of (3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

There total 7 articles about (3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1353049-98-5
C₅₁H₇₁FN₄O₁₃Si₂

: 1353050-22-2
(3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 134523-03-8
lipitor

: 1353050-22-2
(3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 72 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C

3: dimedone / tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 3 h

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

5: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 0 - 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; dimedone; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 915092-85-2
allyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

: 1353050-22-2
(3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C

2: dimedone / tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 3 h

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

4: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 0 - 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; dimedone; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;