4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine

Base Information

• Chemical Name: 4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine
• CAS No.: 906462-78-0
• Molecular Formula: C₁₂H₁₀Cl₂N₂S
• Molecular Weight: 285.197
• Mol file: 906462-78-0.mol

Synonyms:4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine

Chemical Property of 4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine

There total 5 articles about 4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol (906462-77-9) → 4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine (906462-78-0)

Guidance literature:

With trichlorophosphate; at 120 ℃;

DOI:10.1016/j.bmcl.2006.05.045

Reference yield:

3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester (906462-76-8) → 4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine (906462-78-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / thiourea; NaOEt / ethanol / 2 h / 85 °C

2: 95 percent / aq. KOH

3: 85 percent / POCl₃ / 120 °C

With potassium hydroxide; sodium ethanolate; thiourea; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmcl.2006.05.045

Reference yield:

ortho-chlorobenzoic acid (118-91-2) → 4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine (906462-78-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: imidazole

1.2: 75 percent / tetrahydrofuran / 10 h / 20 °C

2.1: 45 percent / NaO-t-Bu / tetrahydrofuran

3.1: 90 percent / thiourea; NaOEt / ethanol / 2 h / 85 °C

4.1: 95 percent / aq. KOH

5.1: 85 percent / POCl₃ / 120 °C

With 1H-imidazole; potassium hydroxide; sodium ethanolate; thiourea; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2006.05.045

upstream raw materials:

6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol

3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester

6-(2-chloro-phenyl)-2-mercapto-5-methyl-pyrimidin-4-ol

ortho-chlorobenzoic acid

Downstream raw materials:

5-bromomethyl-4-chloro-6-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine

[4-chloro-6-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-5-ylmethyl]-(4-methoxy-benzyl)-amine

5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-methylsulfanyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-methanesulfonyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one