3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester
• CAS No.: 906462-76-8
• Molecular Formula: C₁₂H₁₃ClO₃
• Molecular Weight: 240.686
• Mol file: 906462-76-8.mol

Synonyms:3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester

Chemical Property of 3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester

There total 2 articles about 3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

methyl iodide (74-88-4) + ethyl (2-chlorobenzoyl)acetate (19112-35-7) → 3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester (906462-76-8)

Guidance literature:

With sodium t-butanolate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.05.045

Reference yield:

ortho-chlorobenzoic acid (118-91-2) → 3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester (906462-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: imidazole

1.2: 75 percent / tetrahydrofuran / 10 h / 20 °C

2.1: 45 percent / NaO-t-Bu / tetrahydrofuran

With 1H-imidazole; sodium t-butanolate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.05.045

Reference yield: 90.0%

3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester (906462-76-8) → 6-(2-chloro-phenyl)-2-mercapto-5-methyl-pyrimidin-4-ol (906462-84-8)

Guidance literature:

With sodium ethanolate; thiourea; In ethanol; at 85 ℃; for 2h;

DOI:10.1016/j.bmcl.2006.05.045

upstream raw materials:

methyl iodide

ethyl (2-chlorobenzoyl)acetate

ortho-chlorobenzoic acid

Downstream raw materials:

6-(2-chloro-phenyl)-2-mercapto-5-methyl-pyrimidin-4-ol

4-chloro-6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidine

6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol

5-bromomethyl-4-chloro-6-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine