6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol

Base Information

• Chemical Name: 6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol
• CAS No.: 906462-77-9
• Molecular Formula: C₁₂H₁₁ClN₂OS
• Molecular Weight: 266.751
• Mol file: 906462-77-9.mol

Synonyms:6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol

Chemical Property of 6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol

There total 4 articles about 6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-(2-chloro-phenyl)-2-mercapto-5-methyl-pyrimidin-4-ol (906462-84-8) + methyl iodide (74-88-4) → 6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol (906462-77-9)

Guidance literature:

With potassium hydroxide;

DOI:10.1016/j.bmcl.2006.05.045

Reference yield:

3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester (906462-76-8) → 6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol (906462-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / thiourea; NaOEt / ethanol / 2 h / 85 °C

2: 95 percent / aq. KOH

With potassium hydroxide; sodium ethanolate; thiourea; In ethanol;

DOI:10.1016/j.bmcl.2006.05.045

Reference yield:

ortho-chlorobenzoic acid (118-91-2) → 6-(2-chloro-phenyl)-5-methyl-2-methylsulfanyl-pyrimidin-4-ol (906462-77-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: imidazole

1.2: 75 percent / tetrahydrofuran / 10 h / 20 °C

2.1: 45 percent / NaO-t-Bu / tetrahydrofuran

3.1: 90 percent / thiourea; NaOEt / ethanol / 2 h / 85 °C

4.1: 95 percent / aq. KOH

With 1H-imidazole; potassium hydroxide; sodium ethanolate; thiourea; sodium t-butanolate; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2006.05.045

upstream raw materials:

6-(2-chloro-phenyl)-2-mercapto-5-methyl-pyrimidin-4-ol

methyl iodide

3-(2-chloro-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester

ortho-chlorobenzoic acid

Downstream raw materials:

1-[4-chloro-6-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-5-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea

5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-3-(4-methoxy-benzyl)-7-methylsulfanyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-methanesulfonyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one