N-hydroxy-3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanamide

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Chemical Name:N-hydroxy-3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanamide
CAS No.:273936-73-5
Molecular Formula:C₁₅H₂₅NO₄
Molecular Weight:283.368
Hs Code.:

Synonyms:N-hydroxy-3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-hydroxy-3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanamide

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Technology Process of N-hydroxy-3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanamide

There total 5 articles about N-hydroxy-3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 273936-72-4
methyl 3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoate

: 273936-73-5
N-hydroxy-3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanamide

Guidance literature:: With potassium hydroxide; hydroxylamine hydrochloride; In methanol; at 0 ℃; for 2h;
DOI:10.1021/ja9939284

Reference yield:

: 273936-70-2
3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanal

: 273936-73-5
N-hydroxy-3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / NaClO₂; 2-methyl-2-butene; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

2: 88 percent / diethyl ether / 0.5 h / 0 °C

3: 92 percent / NH₂OH*HCl; KOH / methanol / 2 h / 0 °C

With potassium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydroxylamine hydrochloride; In methanol; diethyl ether; water; tert-butyl alcohol; 1: Oxidation / 2: Esterification / 3: amidation;
DOI:10.1021/ja9939284

Reference yield:

: 273936-71-3
3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanoic acid

: 273936-73-5
N-hydroxy-3-{(2E)-2-[(2E)-4-(methoxymethyloxy)-2-butenylidene]cyclohexyl}propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / diethyl ether / 0.5 h / 0 °C

2: 92 percent / NH₂OH*HCl; KOH / methanol / 2 h / 0 °C

With potassium hydroxide; hydroxylamine hydrochloride; In methanol; diethyl ether; 1: Esterification / 2: amidation;
DOI:10.1021/ja9939284