5-(2,6-difluorophenyl)-7-ethenyl-N,N-dimethyl-1H-pyrazolo[4,3-c]isoquinoline-1-sulphonamide

Base Information

Chemical Name:5-(2,6-difluorophenyl)-7-ethenyl-N,N-dimethyl-1H-pyrazolo[4,3-c]isoquinoline-1-sulphonamide
CAS No.:1253734-17-6
Molecular Formula:C₂₀H₁₆F₂N₄O₂S
Molecular Weight:414.435
Hs Code.:

Synonyms:5-(2,6-difluorophenyl)-7-ethenyl-N,N-dimethyl-1H-pyrazolo[4,3-c]isoquinoline-1-sulphonamide

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Chemical Property of 5-(2,6-difluorophenyl)-7-ethenyl-N,N-dimethyl-1H-pyrazolo[4,3-c]isoquinoline-1-sulphonamide

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Technology Process of 5-(2,6-difluorophenyl)-7-ethenyl-N,N-dimethyl-1H-pyrazolo[4,3-c]isoquinoline-1-sulphonamide

There total 5 articles about 5-(2,6-difluorophenyl)-7-ethenyl-N,N-dimethyl-1H-pyrazolo[4,3-c]isoquinoline-1-sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253733-72-0
5-(2,6-difluorophenyl)-7-iodopyrazolo[4,3-c]isoquinoline-1-sulphonic acid dimethylamide

: 7486-35-3
tri-n-butyl(vinyl)tin

: 1253734-17-6
5-(2,6-difluorophenyl)-7-ethenyl-N,N-dimethyl-1H-pyrazolo[4,3-c]isoquinoline-1-sulphonamide

Guidance literature:: palladium-triphenylphosphine; In N,N-dimethyl-formamide; for 3.16667h; Inert atmosphere; Reflux;

Reference yield:

: 18063-02-0
2,6-difluorobenzoylchloride

: 1253734-17-6
5-(2,6-difluorophenyl)-7-ethenyl-N,N-dimethyl-1H-pyrazolo[4,3-c]isoquinoline-1-sulphonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

3.2: 16 h / 20 °C

4.1: palladium-triphenylphosphine / N,N-dimethyl-formamide / 3.17 h / Inert atmosphere; Reflux

With phosphorus pentoxide; sodium hydride; sodium hydroxide; palladium-triphenylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1253733-68-4
3-(4-iodophenyl)-1H-pyrazol-4-ylamine

: 1253734-17-6
5-(2,6-difluorophenyl)-7-ethenyl-N,N-dimethyl-1H-pyrazolo[4,3-c]isoquinoline-1-sulphonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

3.2: 16 h / 20 °C

4.1: palladium-triphenylphosphine / N,N-dimethyl-formamide / 3.17 h / Inert atmosphere; Reflux

With phosphorus pentoxide; sodium hydride; sodium hydroxide; palladium-triphenylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;