ethyl 1-(benzenesulfonyl)-5-fluoro-1H-3-iodoindole-2-carboxylate

Base Information

• Chemical Name: ethyl 1-(benzenesulfonyl)-5-fluoro-1H-3-iodoindole-2-carboxylate
• CAS No.: 1034110-39-8
• Molecular Formula: C₁₇H₁₃FINO₄S
• Molecular Weight: 473.263
• Mol file: 1034110-39-8.mol

Synonyms:ethyl 1-(benzenesulfonyl)-5-fluoro-1H-3-iodoindole-2-carboxylate

Chemical Property of ethyl 1-(benzenesulfonyl)-5-fluoro-1H-3-iodoindole-2-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of ethyl 1-(benzenesulfonyl)-5-fluoro-1H-3-iodoindole-2-carboxylate

There total 1 articles about ethyl 1-(benzenesulfonyl)-5-fluoro-1H-3-iodoindole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate (167631-21-2) + benzenesulfonyl chloride (98-09-9) → ethyl 1-(benzenesulfonyl)-5-fluoro-1H-3-iodoindole-2-carboxylate (1034110-39-8)

Guidance literature:

ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.75h; Inert atmosphere;

benzenesulfonyl chloride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.200800643

Reference yield: 83.0%

ethyl 1-(benzenesulfonyl)-5-fluoro-1H-3-iodoindole-2-carboxylate (1034110-39-8) + 2-formylbenzene boronic acid (40138-16-7) → ethyl 5-fluoro-3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate (1095343-13-7)

Guidance literature:

With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate; cesium fluoride; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200800643

Reference yield: 51.0%

ethyl 1-(benzenesulfonyl)-5-fluoro-1H-3-iodoindole-2-carboxylate (1034110-39-8) + C14H22BNO4 → (R,S)-ethyl 1-(benzenesulfonyl)-3-{2-[1-(tert-butyloxycarbonylamino)propyl]phenyl}-5-fluoro-1H-indole-2-carboxylate (1034110-61-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; for 20h; Inert atmosphere; Reflux;

DOI:10.1021/jm701466p

upstream raw materials:

ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate

benzenesulfonyl chloride

Downstream raw materials:

ethyl 5-fluoro-3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate

(R,S)-ethyl 1-(benzenesulfonyl)-3-{2-[1-(tert-butyloxycarbonylamino)propyl]phenyl}-5-fluoro-1H-indole-2-carboxylate