3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Base Information

Chemical Name:3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide
CAS No.:1070295-25-8
Molecular Formula:C₃₂H₃₅N₃O₂
Molecular Weight:493.649
Hs Code.:

Synonyms:3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

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Chemical Property of 3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Chemical Property:

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Technology Process of 3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

There total 6 articles about 3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070295-28-1
3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester

: 765-30-0
Cyclopropylamine

: 1070295-25-8
3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: 3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester; Cyclopropylamine; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070295-25-8
3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

3.1: bromine / acetic acid / 0.33 h / 20 °C

4.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl-ammonium chloride / ISOPROPYLAMIDE / 2 h / 70 °C

4.3: 0.5 h / 20 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C

With bromine; isopropylmagnesium chloride; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl-ammonium chloride; In tetrahydrofuran; ISOPROPYLAMIDE; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1070292-54-4
4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester

: 1070295-25-8
3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 20 °C

2.1: bromine / acetic acid / 0.33 h / 20 °C

3.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl-ammonium chloride / ISOPROPYLAMIDE / 2 h / 70 °C

3.3: 0.5 h / 20 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C

With bromine; isopropylmagnesium chloride; sodium hydride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl-ammonium chloride; In tetrahydrofuran; ISOPROPYLAMIDE; acetic acid; N,N-dimethyl-formamide;