3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester

Base Information

Chemical Name:3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester
CAS No.:1070295-28-1
Molecular Formula:C₃₀H₃₂N₂O₃
Molecular Weight:468.596
Hs Code.:

Synonyms:3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester

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Chemical Property of 3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester

Chemical Property:

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Technology Process of 3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester

There total 5 articles about 3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070295-26-9
3-(2-benzyl-4-bromo-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester

: 506-59-2
N,N-dimethylammonium chloride

: 107-18-6
allyl alcohol

: 1070295-28-1
3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester

Guidance literature:: 3-(2-benzyl-4-bromo-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester; allyl alcohol; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl-ammonium chloride; In ISOPROPYLAMIDE; at 70 ℃; for 2h;

With hydrogenchloride; In ISOPROPYLAMIDE; water;

N,N-dimethylammonium chloride; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070295-28-1
3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

3.1: bromine / acetic acid / 0.33 h / 20 °C

4.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl-ammonium chloride / ISOPROPYLAMIDE / 2 h / 70 °C

4.3: 0.5 h / 20 °C

With bromine; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl-ammonium chloride; In ISOPROPYLAMIDE; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1070292-54-4
4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester

: 1070295-28-1
3-(2-benzyl-4-(3-(dimethylamino)propyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 20 °C

2.1: bromine / acetic acid / 0.33 h / 20 °C

3.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl-ammonium chloride / ISOPROPYLAMIDE / 2 h / 70 °C

3.3: 0.5 h / 20 °C

With bromine; sodium hydride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl-ammonium chloride; In ISOPROPYLAMIDE; acetic acid; N,N-dimethyl-formamide;