(E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate

Base Information

• Chemical Name: (E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate
• CAS No.: 1391943-72-8
• Molecular Formula: C₁₅H₁₄ClFN₂O₃
• Molecular Weight: 324.739

Synonyms:(E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate

Chemical Property of (E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate

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Technology Process of (E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate

There total 1 articles about (E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate (4415-09-2) → (E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (1391943-72-8)

Guidance literature:

With 1-methyl-1H-imidazole; at 80 ℃; for 6h;

DOI:10.1016/j.tet.2014.04.015

Reference yield: 80.0%

(E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (1391943-72-8) → dimethyl 5,5'-((1E,3Z)-4-(dimethylamino)buta-1,3-diene-1,3-diyl)bis(3-(2-chloro-6-fluorophenyl)isoxazole-4-carboxylate) (1610688-85-1)

Guidance literature:

With acetyl chloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.tet.2014.04.015

Reference yield: 55.0%

(E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (1391943-72-8) → trimethyl 5,5',5-(benzene-1,3,5-triyl)tris(3-(2-chloro-6-fluorophenyl)isoxazole-4-carboxylate) (1610688-91-9)

Guidance literature:

With acetyl chloride; In 1,4-dioxane; at 50 ℃; for 216h;

DOI:10.1016/j.tet.2014.04.015

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

Downstream raw materials:

(E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(dimethylamino)-4,4,5,5-tetrafluoro-3-oxopent-1-en-2-yl)isoxazole-4-carboxylate

dimethyl 5,5'-((1E,3Z)-4-(dimethylamino)buta-1,3-diene-1,3-diyl)bis(3-(2-chloro-6-fluorophenyl)isoxazole-4-carboxylate)

trimethyl 5,5',5-(benzene-1,3,5-triyl)tris(3-(2-chloro-6-fluorophenyl)isoxazole-4-carboxylate)

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