4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile

Base Information

• Chemical Name: 4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile
• CAS No.: 871793-28-1
• Molecular Formula: C₁₅H₁₀F₃N₃O
• Molecular Weight: 305.259
• Mol file: 871793-28-1.mol

Synonyms:4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile

Chemical Property of 4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile

There total 5 articles about 4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile (871793-23-6) → 4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile (871793-28-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2010.08.101

Reference yield:

2-methanesulphonyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)-pyrimidine → 4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile (871793-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 0.75 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 0.75 h / 20 °C

With Dess-Martin periodane; In dichloromethane; dimethyl sulfoxide;

Reference yield:

2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine (871793-25-8) → 4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile (871793-28-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium peroxymonosulfate / methanol; water / 3 h / 20 °C

2: dimethyl sulfoxide / 0.75 h / 20 °C

3: Dess-Martin periodane / dichloromethane / 0.75 h / 20 °C

With potassium peroxymonosulfate; Dess-Martin periodane; In methanol; dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile

1,3-dioxo-6-hydroxy-1-(3-trifluoromethylphenyl)-hexane

2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine

3'-(trifluoromethyl)acetophenone

Downstream raw materials:

C₂₀H₂₀F₃N₅O