(3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester

Base Information

• Chemical Name: (3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester
• CAS No.: 300355-12-8
• Molecular Formula: C₁₁H₁₃ClO₃S
• Molecular Weight: 260.741
• Mol file: 300355-12-8.mol

Synonyms:(3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester

Chemical Property of (3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester

There total 2 articles about (3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

(3-chloro-4-methylsulfanyl-phenyl)-oxo-acetic acid ethyl ester (300355-11-7) → (3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester (300355-12-8)

Guidance literature:

With sodium borohydrid; In methanol;

Reference yield:

2-chlorothioanisole (17733-22-1) → (3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester (300355-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / chloroform / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 0.25 h / 0 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; In methanol; chloroform;

DOI:10.1021/jm3008689

Reference yield: 91.0%

(3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester (300355-12-8) → acetoxy(3-chloro-4-methylsulfanylphenyl)acetic acid ethyl ester (300355-13-9)

Guidance literature:

With dmap; acetic anhydride; In pyridine;

upstream raw materials:

(3-chloro-4-methylsulfanyl-phenyl)-oxo-acetic acid ethyl ester

2-chlorothioanisole

Downstream raw materials:

acetoxy(3-chloro-4-methylsulfanylphenyl)acetic acid ethyl ester

(3-chloro-4-methylsulfanylphenyl)acetic acid ethyl ester

2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester

2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid