2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid

Base Information

• Chemical Name: 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid
• CAS No.: 300355-16-2
• Molecular Formula: C₁₅H₁₉ClO₂S
• Molecular Weight: 298.834
• Mol file: 300355-16-2.mol

Synonyms:2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid

Chemical Property of 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid

There total 7 articles about 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

aqueous potassium hydroxide + 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester (300355-15-1) → 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid (300355-16-2)

Guidance literature:

In ethanol;

Reference yield: 70.0%

2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester (300355-15-1) → 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid (300355-16-2)

Guidance literature:

With water; potassium hydroxide; In ethanol; at 25 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm3008689

Reference yield:

2-chlorothioanisole (17733-22-1) → 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid (300355-16-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / chloroform / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 0.25 h / 0 °C / Inert atmosphere

3.1: pyridine; dmap / 16 h / 25 °C / Inert atmosphere

4.1: N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide / tetrahydrofuran; methanol / 0.1 h / 25 °C / Inert atmosphere

5.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 16 h / -78 - 25 °C / Inert atmosphere

6.1: potassium hydroxide; water / ethanol / 16 h / 25 °C / Inert atmosphere

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; aluminum (III) chloride; sodium tetrahydroborate; n-butyllithium; samarium diiodide; water; diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; chloroform;

DOI:10.1021/jm3008689

upstream raw materials:

2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester

2-chlorothioanisole

(3-chloro-4-methylsulfanyl-phenyl)-oxo-acetic acid ethyl ester

(3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester

Downstream raw materials:

2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentyl-N-thiazol-2-yl-propionamide

3-cyclopentyl-2-(3-chloro-4-methanesulfonylphenyl)propionic acid