2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester

Base Information

Chemical Name:2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester
CAS No.:300355-15-1
Molecular Formula:C₁₇H₂₃ClO₂S
Molecular Weight:326.887
Hs Code.:

Synonyms:2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester

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Chemical Property of 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester

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Technology Process of 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester

There total 5 articles about 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 300355-14-0
(3-chloro-4-methylsulfanylphenyl)acetic acid ethyl ester

: 27935-87-1
cyclopentylmethyl Iodide

: 300355-15-1
2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester

Guidance literature:: With hydrogenchloride; n-butyllithium; diisopropylamine; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone;

Reference yield:

: 17733-22-1
2-chlorothioanisole

: 300355-15-1
2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / chloroform / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 0.25 h / 0 °C / Inert atmosphere

3.1: pyridine; dmap / 16 h / 25 °C / Inert atmosphere

4.1: N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide / tetrahydrofuran; methanol / 0.1 h / 25 °C / Inert atmosphere

5.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 16 h / -78 - 25 °C / Inert atmosphere

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; aluminum (III) chloride; sodium tetrahydroborate; n-butyllithium; samarium diiodide; diisopropylamine; In tetrahydrofuran; methanol; hexane; chloroform;
DOI:10.1021/jm3008689

Reference yield:

: 300355-12-8
(3-chloro-4-methylsulfanyl-phenyl)hydroxyacetic acid ethyl ester

: 300355-15-1
2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; dmap / 16 h / 25 °C / Inert atmosphere

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide / tetrahydrofuran; methanol / 0.1 h / 25 °C / Inert atmosphere

3.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 16 h / -78 - 25 °C / Inert atmosphere

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; samarium diiodide; diisopropylamine; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jm3008689