144464-65-3

Upstream product

• 22009-38-7 7-hydroxy-1-tetralone 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 116047-26-8 methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate 
• 229006-58-0 7-(4-methylphenyl)-3,4-dihydronaphthalen-1(2H)-one 
• 144464-67-5 8-Oxo-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid pentafluorophenyl ester 
• 776328-39-3 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 
• 204588-68-1 1-[7-((S)-N-(1-benzyloxycarbonylethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose 
• 204588-69-2 1-[7-((R)-N-(1-benzyloxycarbonylethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose 
• 204588-66-9 1-[7-methoxycarbonyl-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose 
• 204588-67-0 1-[7-carboxy-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose 
• 204588-76-1 1-{7-[3-(benzyloxycarbonyl)propyl]-1,2,3,4-tetrahydro-1(R,S)-naphthyl}-2,3,4-tri-O-benzyl-α-L-fucopyranose 
• 204588-70-5 1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose 
• 204588-75-0 7-[3-(benzyloxycarbonyl)propyl]-1,2,3,4-tetrahydro-1-naphthol 
• 204588-74-9 7-[3-(benzyloxycarbonyl)propyl]-1,2,3,4-tetrahydronaphthalen-1-one 
• 229003-49-0 7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide 
• 229003-44-5 7-phenyl-N-[4-(2-piperidinoethyl)phenyl]-3,4-dihydro-naphthalene-2-carboxamide 

Relevant academic research and scientific papers

4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE

Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.

Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors

With the aim of discovering a novel class of fructose-1,6-bisphosphatase (FBPase) inhibitors, a series of compounds based on tricyclic scaffolds was synthesized. Extensive SAR studies led to the finding of 8l with an IC50 value of 0.013 μM against human FBPase. An X-ray crystallographic study revealed that 8l bound at AMP binding sites of human liver FBPase with hydrogen bonding interactions similar to AMP.

A ring expansion strategy in antiviral synthesis: A novel approach to TAK-779

A synthesis of TAK-779 that relies on construction of a key carboxylic acid intermediate by a ring expansion with TMSCHN2 is described.

AMINO ACID DERIVATIVE

The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibition activity.This amino acid derivative is represented by the following general formula (I): STR1 wherein R 1 represents a hydrogen atom or an acyl group; R 2 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, an ary group which may have a substituent, a heteroaryl group which may have a substituent, an arylalkyl group which may have a substituent or a heteroarylalkyl group which may have a substituent;m and n represent each independently an integer of 0, 1 or 2 and J represents a cyclic group having an angiotensin I-converting enzyme inhibition activity.

Synthesis of Benzoic and Tetralone Carboxylic Acid Esters from Phenols by Palladium Catalyzed Alkoxy/Aryloxy Carbonylation

Various phenols with an acyl group conjugated to the aromatic system were converted via trifluoromethanesulfonates into benzoic acid esters by a palladium catalyzed alkoxy/aryloxy carbonylation.