benzyl (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)piperidine-1-carboxylate
CAS No.:1268685-13-7
Molecular Formula:C₂₁H₂₉NO₄
Molecular Weight:359.466
Hs Code.:

Synonyms:benzyl (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)piperidine-1-carboxylate

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Chemical Property of benzyl (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)piperidine-1-carboxylate

There total 5 articles about benzyl (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₂₁NO₂

: 501-53-1,94274-21-2
benzyl chloroformate

: 1268685-13-7
benzyl (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)piperidine-1-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2010.12.020

Reference yield:

: 1268685-02-4
(S)-N-benzyl-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-en-1-amine

: 1268685-13-7
benzyl (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutylammomium bromide; sodium hydrogencarbonate / acetonitrile / 4 h / Reflux; Inert atmosphere

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 6 h / 90 °C / Inert atmosphere

3: 20 % Pd(OH)2/C; hydrogen / methanol / 12 h / 20 °C

4: sodium hydrogencarbonate / water; ethyl acetate / 1 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 20 % Pd(OH)2/C; tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; In methanol; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2010.12.020

Reference yield:

: 1333213-22-1
C₁₆H₂₁NO₂

: 1268685-13-7
benzyl (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: cerium(III) chloride heptahydrate; zinc / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: tetrabutylammomium bromide; sodium hydrogencarbonate / acetonitrile / 4 h / Reflux; Inert atmosphere

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 6 h / 90 °C / Inert atmosphere

4: 20 % Pd(OH)2/C; hydrogen / methanol / 12 h / 20 °C

5: sodium hydrogencarbonate / water; ethyl acetate / 1 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; cerium(III) chloride heptahydrate; 20 % Pd(OH)2/C; tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; zinc; In tetrahydrofuran; methanol; water; ethyl acetate; toluene; acetonitrile; 1: Barbier reaction;
DOI:10.1016/j.tetlet.2010.12.020