(S)-N-(benzyloxycarbonyl)-2-formylpiperidine

Base Information

• Chemical Name: (S)-N-(benzyloxycarbonyl)-2-formylpiperidine
• CAS No.: 212556-95-1
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.294
• Mol file: 212556-95-1.mol

Synonyms:(S)-N-(benzyloxycarbonyl)-2-formylpiperidine

Chemical Property of (S)-N-(benzyloxycarbonyl)-2-formylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-N-(benzyloxycarbonyl)-2-formylpiperidine

There total 20 articles about (S)-N-(benzyloxycarbonyl)-2-formylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester (212557-00-1) → (S)-N-(benzyloxycarbonyl)-2-formylpiperidine (212556-95-1)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃;

DOI:10.1016/j.tet.2013.05.055

Reference yield: 17.0%

benzyl (S)-2-([1,3]dithian-2-yl)piperidine-1-carboxylate (1067639-60-4) → (S)-N-(benzyloxycarbonyl)-2-formylpiperidine (212556-95-1)

Guidance literature:

benzyl (S)-2-([1,3]dithian-2-yl)piperidine-1-carboxylate; With bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; methanol; at 20 ℃; for 0.25h;

With toluene-4-sulfonic acid; In 1,3-dioxane; water; at 50 ℃; for 3h; enantioselective reaction;

DOI:10.1055/s-2008-1067176

Reference yield:

benzyl-(2S)-2-[(1S)-1,2-dihydroxyethyl]piperidine-1-carboxylate → (S)-N-(benzyloxycarbonyl)-2-formylpiperidine (212556-95-1)

Guidance literature:

With sodium periodate; In tetrahydrofuran; water; for 0.25h; Cooling with ice;

DOI:10.1016/j.tetlet.2010.12.020

upstream raw materials:

(S)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester

1-benzyloxycarbonyl-2-hydroxymethylpiperidine

benzyl chloroformate

piperidin-2-ylmethanol

Downstream raw materials:

(S)-2-((E)-2-Methoxycarbonyl-vinyl)-piperidine-1-carboxylic acid benzyl ester

(S)-1-(carbobenzyloxy)-2-piperidinecarboxylic acid

(+)-lentiginosine

(S)-2-((1S,2R)-2-Ethoxycarbonyl-1,2-dihydroxy-ethyl)-piperidine-1-carboxylic acid benzyl ester