(±)-ethyl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoate

Base Information

Chemical Name:(±)-ethyl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoate
CAS No.:1431884-97-7
Molecular Formula:C₂₂H₂₂N₂O₅
Molecular Weight:394.427
Hs Code.:

Synonyms:(±)-ethyl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-ethyl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoate

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Technology Process of (±)-ethyl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoate

There total 2 articles about (±)-ethyl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 40149-83-5
2-(2-iodoethyl)isoindoline-1,3-dione

: 59050-15-6
ethyl 3-(N-methyl-N-phenylamino)-3-oxopropionate

: 1431884-97-7
(±)-ethyl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoate

Guidance literature:: ethyl 3-(N-methyl-N-phenylamino)-3-oxopropionate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

2-(2-iodoethyl)isoindoline-1,3-dione; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/ol400899e

Reference yield:

: 1071-46-1
hydrogen ethyl malonate

: 1431884-97-7
(±)-ethyl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; triethylamine / tetrahydrofuran / 0.33 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 1.5 h / 20 °C / Inert atmosphere

With sodium hydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol400899e