2-Amino-4-chloro-3-hydroxybenzoic acid

Base Information

Chemical Name:2-Amino-4-chloro-3-hydroxybenzoic acid
CAS No.:23219-33-2
Molecular Formula:C7H6 Cl N O3
Molecular Weight:187.583
Hs Code.:2922509090
UNII:R67LEH4X5Q
DSSTox Substance ID:DTXSID30177794
Nikkaji Number:J413.102I
Wikidata:Q27095338
Metabolomics Workbench ID:149037
ChEMBL ID:CHEMBL1230244
Mol file:23219-33-2.mol

Synonyms:4-chloro-3-hydroxyanthranilate;4-chloro-3-hydroxyanthranilic acid;4-Cl-3-hana

Suppliers and Price of 2-Amino-4-chloro-3-hydroxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Ambeed
2-Amino-4-chloro-3-hydroxybenzoicacid 95%
5g
$ 1493.00

Ambeed
2-Amino-4-chloro-3-hydroxybenzoicacid 95%
1g
$ 419.00

Ambeed
2-Amino-4-chloro-3-hydroxybenzoicacid 95%
250mg
$ 175.00

Ambeed
2-Amino-4-chloro-3-hydroxybenzoicacid 95%
100mg
$ 121.00

Activate Scientific
2-Amino-4-chloro-3-hydroxybenzoicacid 95%
5 g
$ 1862.00

Total 5 raw suppliers

Chemical Property of 2-Amino-4-chloro-3-hydroxybenzoic acid

Chemical Property:

Vapor Pressure:6.24E-06mmHg at 25°C
Boiling Point:363.8°Cat760mmHg
Flash Point:173.8°C
PSA：83.55000
Density:1.636g/cm³
LogP:1.90720
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:187.0036207
Heavy Atom Count:12
Complexity:188

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-chloro-3-hydroxybenzoicacid 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1C(=O)O)N)O)Cl

Technology Process of 2-Amino-4-chloro-3-hydroxybenzoic acid

There total 9 articles about 2-Amino-4-chloro-3-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 129634-23-7
2-(2-amino-4-chloro-3-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 23219-33-2
4-chloro-3-hydroxyanthranilic acid

Guidance literature:: With hydrogen bromide; for 18h; Heating;
DOI:10.1016/0223-5234(90)90210-T

Reference yield:

: 18734-74-2
2-nitro-3-hydroxy-4-chlorobenzoic acid

: 23219-33-2
4-chloro-3-hydroxyanthranilic acid

Guidance literature:: With hydrogen; Ra-Ni; In methanol;

Reference yield:

: 615-74-7
2-chloro-5-methylphenol

: 23219-33-2
4-chloro-3-hydroxyanthranilic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / sodium carbonate / acetone / 24 h / Heating

2: 65 percent / KMnO₄ / H₂O / 3 h / Heating

3: SOCl₂ / benzene / 1 h / Heating

4: 2.) SOCl₂ / 1.) CH₂Cl₂, RT, overnight, 2.) Et₂O, RT, 1 h

5: 1.) 1.6N n-butyllithium, 2.) p-toluenesulfonylazide / 1.) ether, hexane, -40 deg C, 45 min, 2.) -40 deg C, 4 h

6: 79 percent / hexadecyl tributylphosphonium bromide, NaBH₄ / toluene; H₂O / 24 h / 80 °C

7: 52 percent / 48percent HBr / 18 h / Heating

With sodium tetrahydroborate; potassium permanganate; n-butyllithium; thionyl chloride; 4-toluenesulfonyl azide; hydrogen bromide; sodium carbonate; cetyltributylphosphonium bromide; In water; acetone; toluene; benzene;
DOI:10.1016/0223-5234(90)90210-T