Technology Process of 2-(2-amino-4-chloro-3-methoxyphenyl)-4,4-dimethyl-2-oxazoline
There total 6 articles about 2-(2-amino-4-chloro-3-methoxyphenyl)-4,4-dimethyl-2-oxazoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; cetyltributylphosphonium bromide;
In
water; toluene;
at 80 ℃;
for 24h;
DOI:10.1016/0223-5234(90)90210-T
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 87 percent / sodium carbonate / acetone / 24 h / Heating
2: 65 percent / KMnO4 / H2O / 3 h / Heating
3: SOCl2 / benzene / 1 h / Heating
4: 2.) SOCl2 / 1.) CH2Cl2, RT, overnight, 2.) Et2O, RT, 1 h
5: 1.) 1.6N n-butyllithium, 2.) p-toluenesulfonylazide / 1.) ether, hexane, -40 deg C, 45 min, 2.) -40 deg C, 4 h
6: 79 percent / hexadecyl tributylphosphonium bromide, NaBH4 / toluene; H2O / 24 h / 80 °C
With
sodium tetrahydroborate; potassium permanganate; n-butyllithium; thionyl chloride; 4-toluenesulfonyl azide; sodium carbonate; cetyltributylphosphonium bromide;
In
water; acetone; toluene; benzene;
DOI:10.1016/0223-5234(90)90210-T
- Guidance literature:
-
Multi-step reaction with 4 steps
1: SOCl2 / benzene / 1 h / Heating
2: 2.) SOCl2 / 1.) CH2Cl2, RT, overnight, 2.) Et2O, RT, 1 h
3: 1.) 1.6N n-butyllithium, 2.) p-toluenesulfonylazide / 1.) ether, hexane, -40 deg C, 45 min, 2.) -40 deg C, 4 h
4: 79 percent / hexadecyl tributylphosphonium bromide, NaBH4 / toluene; H2O / 24 h / 80 °C
With
sodium tetrahydroborate; n-butyllithium; thionyl chloride; 4-toluenesulfonyl azide; cetyltributylphosphonium bromide;
In
water; toluene; benzene;
DOI:10.1016/0223-5234(90)90210-T
