129634-23-7Relevant academic research and scientific papers
Regioselective synthesis of 4-chloro-3-hydroxyanthranilic acid, a potent in vitro inhibitor of 3-hydroxyanthranilic acid oxygenase activity from rat brain
Melikian,Boigegrain,Kan,Soubrie
, p. 267 - 270 (2007/10/02)
In the kynurenine metabolic pathways of tryptophan in kidney, liver and brain, 3-hydroxyanthranilic oxygenase (3-HAO, EC 1.13.11.6) catalyses the conversion of 3-hydroxyanthranilic acid to quinolinic acid, an excitatory amino acid putatively involved in brain neurodegenerative disorders. The compound 4-chloro-3-hydroxyanthranilic acid is an irreversible inhibitor of 3-HAO in the liver and the kidney. We describe here a new, unambiguous regioselective synthesis of this inhibitor and verify its activity on 3-HAO at the brain level.
