TCBOC-Phe-OH

Base Information

Chemical Name:TCBOC-Phe-OH
CAS No.:100167-06-4
Molecular Formula:C₁₄H₁₆Cl₃NO₄
Molecular Weight:368.644
Hs Code.:

Synonyms:TCBOC-Phe-OH

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Chemical Property of TCBOC-Phe-OH

Chemical Property:

Boiling Point:481.6±45.0 °C(Predicted)
Density:1.402±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of TCBOC-Phe-OH

There total 1 articles about TCBOC-Phe-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 66270-36-8
2,2,2-trichloro-1,1-dimethylethoxychloroformate

: 100167-06-4
TCBOC-Phe-OH

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; diethyl ether; water; at 0 ℃; for 12h;

Reference yield: 93.0%

: {(C₅H₅)Fe(C₅H₄)CH₂NHCH(CH₂CH(CH₃)2)CO₂(C(CH₃)3)}

: 100167-06-4
TCBOC-Phe-OH

: (Cl₃C)C(CH₃)2O₂CNHCH(CH₂C₆H₅)CON(CH₂((C₅H₄)Fe(C₅H₅)))CH(CH₂(CH(CH₃)2))CO₂(C(CH₃)3)

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; byproducts: dicyclohexylurea; addn. of the carbodiimide in CH2Cl2 to a soln. of the amino acid at -20°C,12 h without cooling; filtn., concn. of the filtrate, chromy. (silicagel, hexan/ethyl acetate);

Reference yield:

: 100167-06-4
TCBOC-Phe-OH

: 28635-78-1
L-phenylalanyl-L-leucine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) N-hydroxysuccinimide, N-morpholinoethylisocyanid / 1) CH₂Cl₂, 30 min., 2) CH₂Cl₂, 3 h

2: 98 percent / NaBH₄, Co(II)phthalocyanine / ethanol / 20 h / ice cooling

With sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; morpholino-ethyl isocyanide; cobalt(II) phthalocyanine; In ethanol;