(S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine

Base Information

Chemical Name:(S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine
CAS No.:1310877-35-0
Molecular Formula:C₃₀H₃₄FN₃O₅
Molecular Weight:535.615
Hs Code.:

Synonyms:(S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine

Suppliers and Price of (S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine

There total 12 articles about (S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1310877-34-9
(S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

: 1310877-35-0
(S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine

Guidance literature:: With methanol; water; potassium carbonate; In tetrahydrofuran; at 60 ℃; for 7h;
DOI:10.1021/acs.jmedchem.8b00002

Reference yield:

: 1310877-29-2
N-(3-((S)-2-(((R)-tert-butylsulfinyl)amino)-4-oxopentan-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

: 1310877-35-0
(S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

2: potassium carbonate / ethyl acetate; toluene / 1 h / 0 °C / Cooling with ice

3: tetrahydrofuran / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / Reflux

6: potassium carbonate; water / tetrahydrofuran / 20 h / 40 °C

With hydrogenchloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 1310877-28-1
N-(3-((S)-2-(((R)-tert-butylsulfinyl)amino)-4-methylpent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

: 1310877-35-0
(S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine; ozone / dichloromethane / 1 h / -78 °C / Cooling with acetone-dry ice; Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

3: potassium carbonate / ethyl acetate; toluene / 1 h / 0 °C / Cooling with ice

4: tetrahydrofuran / 16 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / Reflux

7: potassium carbonate; water / tetrahydrofuran / 20 h / 40 °C

With hydrogenchloride; water; potassium carbonate; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; toluene; acetonitrile;