(S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:(S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide
CAS No.:1310877-34-9
Molecular Formula:C₃₂H₃₃F₄N₃O₆
Molecular Weight:631.624
Hs Code.:

Synonyms:(S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

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Chemical Property of (S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

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Technology Process of (S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

There total 11 articles about (S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (S)-N-(3-(2-(3,3-bis(2,4-dimethoxybenzyl)ureido)-4-oxopentan-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

: 1310877-34-9
(S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With Burgess Reagent; pyridinium p-toluenesulfonate; In tetrahydrofuran; for 1.5h; Reflux;
DOI:10.1021/acs.jmedchem.8b00002

Reference yield:

: C₃₃H₃₇F₄N₃O₆S

: 1310877-34-9
(S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 48h; Reflux;

Reference yield:

: 1310877-29-2
N-(3-((S)-2-(((R)-tert-butylsulfinyl)amino)-4-oxopentan-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

: 1310877-34-9
(S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

2: potassium carbonate / ethyl acetate; toluene / 1 h / 0 °C / Cooling with ice

3: tetrahydrofuran / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / Reflux

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; toluene; acetonitrile;