219583-65-0

Upstream product

• 100945-15-1 N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester 
• 3163-76-6 benzene-1,3,5-trialdehyde 
• 219583-57-0 2-benzyloxycarbonylamino-3-[3,5-bis-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester 

Downstream Products

• 323202-16-0 (S,S,S)-2,2'-bis(tert-butyloxycarbonylamino)-3,3'-{5-[(2-tert-butyloxycarbonylamino)-2-(methoxycarbonyl)ethyl]-1,3-phenylene}bis(propanoic acid) 
• 323202-15-9 dimethyl (S,S,S)-2,2'-bis(tert-butyloxycarbonylamino)-3,3'-{5-[(2-tert-butyloxycarbonylamino)-2-(methoxycarbonyl)ethyl]-1,3-phenylene}bis(propanoate) 
• 221700-27-2 (S,S,S)-2-amino-3-[3,5-bis(2-amino-2-(methoxycarbonyl)ethyl)phenyl]propanoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation

Here, we report the first synthesis of quasi-stable trimer models of full-length Aβ40 with a toxic conformation using a 1,3,5-phenyltris-l-alanyl linker at position 34, 36, or 38. The only trimer to exhibit weak neurotoxicity against SH-SY5Y cells was the one which was linked at position 38. This suggests that such a propeller-type trimer model is not prone to forming oligomers with potent neurotoxicity, which is in contrast with its corresponding dimer model.

Phenyltrisalanine: A new, C3-symmetric, trifunctional amino acid

Two derivatives of phenyltrisalanine, a new, trifunctional amino acid, were synthesised in optically active forms. Two complementary techniques were employed, an HWE olefination reaction or a Heck coupling reaction, and the resulting dehydroamino acids were hydrogenated using a chiral Rh(I)-Et- DuPHOS catalyst. Phenyltrisalanine derivatives of excellent stereoisomeric purities were thus obtained.