(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Base Information

Chemical Name:(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate
CAS No.:1402883-35-5
Molecular Formula:C₁₆H₁₇N₃O₃
Molecular Weight:299.329
Hs Code.:

Synonyms:(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Suppliers and Price of (1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

There total 6 articles about (1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₄N₃O₃^(1-)*Na⁽¹⁺⁾

: 74-88-4
methyl iodide

: 1402883-35-5
(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm3011405

Reference yield:

: 96847-52-8
(1R,2S)-2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane

: 1402883-35-5
(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 1 h / 20 °C

2.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 25 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 20 °C

3.2: 20 - 80 °C

4.1: sodium ethanolate / ethanol / 95 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With ruthenium trichloride; sodium periodate; sodium ethanolate; potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3011405

Reference yield:

: 1402883-33-3
sodium (1R,2S)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylate

: 1402883-35-5
(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 25 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / acetonitrile / 20 °C

2.2: 20 - 80 °C

3.1: sodium ethanolate / ethanol / 95 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With ruthenium trichloride; sodium periodate; sodium ethanolate; potassium carbonate; 1,1'-carbonyldiimidazole; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3011405