(1R,2S)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

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Chemical Name:(1R,2S)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate
CAS No.:1402883-36-6
Molecular Formula:C₂₆H₃₃N₃O₇
Molecular Weight:499.564
Hs Code.:

Synonyms:(1R,2S)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

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Chemical Property of (1R,2S)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

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Technology Process of (1R,2S)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

There total 7 articles about (1R,2S)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1402883-35-5
(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

: 1402883-36-6
(1R,2S)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm3011405

Reference yield:

: C₁₅H₁₄N₃O₃^(1-)*Na⁽¹⁺⁾

: 1402883-36-6
(1R,2S)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: dmap / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3011405

Reference yield:

: 96847-52-8
(1R,2S)-2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane

: 1402883-36-6
(1R,2S)-methyl 2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 1 h / 20 °C

2.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 25 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 20 °C

3.2: 20 - 80 °C

4.1: sodium ethanolate / ethanol / 95 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: dmap / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; ruthenium trichloride; sodium periodate; sodium ethanolate; potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3011405