{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate

Base Information

Chemical Name:{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate
CAS No.:1607590-42-0
Molecular Formula:C₁₉H₂₀N₄O₂S
Molecular Weight:368.459
Hs Code.:

Synonyms:{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate

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Chemical Property of {1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate

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Technology Process of {1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate

There total 11 articles about {1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.5%

: 51076-95-0
2-chloro-1,1,1-triethoxyethane

: 1607589-86-5
{trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile

: 64-19-7,77671-22-8
acetic acid

: 1607590-41-9
{trans-4-[2-(chloromethyl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile

: 1607590-42-0
{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate

Guidance literature:: at 120 ℃; for 0.5h;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607590-42-0
{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: 0.5 h / 120 °C

With palladium 10% on activated carbon; hydrogen; tetrabutylammonium nitrate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 104515-05-1,905735-40-2
6-nitrothieno[3,2-b]pyridin-7-ol

: 1607590-42-0
{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}methyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 1 h / Reflux

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

4: 0.5 h / 120 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; isopropyl alcohol;