Technology Process of (1S,2S)-2-(3-(methoxymethoxy)phenyl)cyclopropanecarboxylic acid
There total 5 articles about (1S,2S)-2-(3-(methoxymethoxy)phenyl)cyclopropanecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine hydrate; potassium hydroxide;
In
ethylene glycol;
at 120 ℃;
for 168h;
DOI:10.1016/j.bmc.2010.12.024
- Guidance literature:
-
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 13 h / 20 °C
2: hydrazine hydrate; potassium hydroxide / ethylene glycol / 168 h / 120 °C
With
benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide;
In
ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.024
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C
1.2: 6 h / 20 °C
1.3: pH 4
2.1: potassium hydroxide / methanol / 0 - 20 °C
2.2: pH 1
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 13 h / 20 °C
4.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 168 h / 120 °C
With
sodium hydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide;
In
methanol; ethylene glycol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
1.2: Corey-Chaykovsky reaction;
DOI:10.1016/j.bmc.2010.12.024
