tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate

Base Information

Chemical Name:tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate
CAS No.:1314933-58-8
Molecular Formula:C₃₂H₃₇N₃O₅
Molecular Weight:543.663
Hs Code.:

Synonyms:tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate

Suppliers and Price of tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate

There total 13 articles about tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1196052-94-4
(S)-N-(1-benzylcarbamoyl-3-hydroxypropyl)benzamide

: tert-butyl ((1S,2R)-2-(3-hydroxyphenyl)cyclopropyl)carbamate

: 1314933-58-8
tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 10h;
DOI:10.1016/j.bmc.2010.12.024

Reference yield:

: 1257636-03-5
(S)-2-amino-N-benzyl-4-hydroxybutanamide hydrochloride

: 1314933-58-8
tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 10 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2010.12.024

Reference yield:

: 1196052-81-9
methyl trans-3-(3-methoxymethoxyphenyl)propenoate

: 1314933-58-8
tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C

1.2: 6 h / 20 °C

1.3: pH 4

2.1: potassium hydroxide / methanol / 0 - 20 °C

2.2: pH 1

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 13 h / 20 °C

4.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 168 h / 120 °C

5.1: diphenyl phosphoryl azide; triethylamine / cyclohexane / 0 °C / Inert atmosphere; Reflux

6.1: hydrogenchloride / dichloromethane; ethyl acetate / 2.5 h / 20 °C

7.1: triethylamine / 1,4-dioxane; water / 9 h / 20 °C

8.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 10 h / 0 - 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; cyclohexane; water; ethylene glycol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil; 1.2: Corey-Chaykovsky reaction / 5.1: Curtius rearrangement / 8.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2010.12.024