3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one

Base Information

Chemical Name:3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one
CAS No.:1420990-52-8
Molecular Formula:C₁₇H₁₀BrClN₄OS₂
Molecular Weight:465.782
Hs Code.:

Synonyms:3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one

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Chemical Property of 3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one

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Technology Process of 3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one

There total 10 articles about 3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1420990-51-7
6-amino-3-benzyl-7-bromoquinazolin-4(3H)-one

: 75318-43-3
4,5-dichloro-1,2,3-dithiazolium chloride

: 1420990-52-8
3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one

Guidance literature:: 6-amino-3-benzyl-7-bromoquinazolin-4(3H)-one; 4,5-dichloro-1,2,3-dithiazolium chloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With pyridine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ml300429p

Reference yield:

: 1420990-50-6
3-benzyl-7-bromo-6-nitroquinazolin-4(3H)-one

: 1420990-52-8
3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; iron / ethanol / 1 h / Reflux

2.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

With iron; acetic acid; In ethanol; dichloromethane;
DOI:10.1021/ml300429p

Reference yield:

: 99277-71-1
4-bromo-2-nitrobenzoic acid

: 1420990-52-8
3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: indium(III) chloride / 0.67 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: sulfuric acid; nitric acid / 1 h / 100 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 80 °C / Microwave irradiation

4.1: acetic acid; iron / ethanol / 1 h / Reflux

5.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

5.2: 1 h / 20 °C

With indium(III) chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml300429p