3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester

Base Information

Chemical Name:3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester
CAS No.:1562399-45-4
Molecular Formula:C₁₆H₂₁F₃O₃
Molecular Weight:318.336
Hs Code.:

Synonyms:3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester

Suppliers and Price of 3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester

There total 4 articles about 3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 1562399-44-3
3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid

: 1562399-45-4
3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester

Guidance literature:: With sulfuric acid; at 20 ℃; for 16h; Inert atmosphere; Reflux;
DOI:10.1021/jm4019178

Reference yield:

: 400-31-7
1,1,1-trifluoro-4-methyl-pent-3-en-2-one

: 1562399-45-4
3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide / tetrahydrofuran / 2 h / -20 - 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / acetic acid methyl ester / 0.5 h / -65 °C / Inert atmosphere

2.2: 70 h / 20 °C / Inert atmosphere

3.1: sulfuric acid / 16 h / 20 °C / Inert atmosphere; Reflux

With copper(l) iodide; sulfuric acid; lithium hexamethyldisilazane; In tetrahydrofuran; acetic acid methyl ester;
DOI:10.1021/jm4019178

Reference yield:

: 932-31-0
ortho-tolylmagnesium bromide

: 1562399-45-4
3-hydroxy-5-methyl-5-o-tolyl-3-trifluoromethylhexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide / tetrahydrofuran / 2 h / -20 - 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / acetic acid methyl ester / 0.5 h / -65 °C / Inert atmosphere

2.2: 70 h / 20 °C / Inert atmosphere

3.1: sulfuric acid / 16 h / 20 °C / Inert atmosphere; Reflux

With copper(l) iodide; sulfuric acid; lithium hexamethyldisilazane; In tetrahydrofuran; acetic acid methyl ester;
DOI:10.1021/jm4019178