tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate

Base Information

Chemical Name:tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate
CAS No.:1265750-11-5
Molecular Formula:C₁₇H₂₅N₃O₄
Molecular Weight:335.403
Hs Code.:

Synonyms:tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate

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Chemical Property of tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate

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Technology Process of tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate

There total 2 articles about tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1265323-64-5
tert-butyl 1-(2-(4-cyanophenyl)-2-hydroxyethyl)azetidine-3-carboxylate

: 1265750-11-5
tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate

Guidance literature:: With hydroxylamine hydrochloride; sodium hydrogencarbonate; In isopropyl alcohol; at 85 ℃;

Reference yield:

: tert-butyl 1-(2-(4-cyanophenyl)-2-oxoethyl)azetidine-3-carboxylate hydrobromide

: 1265750-11-5
tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 1 h

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 85 °C

With sodium tetrahydroborate; hydroxylamine hydrochloride; sodium hydrogencarbonate; In methanol; isopropyl alcohol;

Reference yield:

: 1236188-83-2
3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride

: 1265750-11-5
tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate

: 429-41-4
tetrabutyl ammonium fluoride

: 1265322-15-3
1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt

Guidance literature:: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride; tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 1h;

tetrabutyl ammonium fluoride; In acetonitrile;

With trifluoroacetic acid;