1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt

Base Information

Chemical Name:1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt
CAS No.:1265322-15-3
Molecular Formula:C₁₆H₃₆N*C₂₄H₁₈F₃N₄O₅
Molecular Weight:741.894
Hs Code.:

1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt

Synonyms:1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt

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Chemical Property of 1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt

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Technology Process of 1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt

There total 7 articles about 1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1265322-15-3
1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt

Guidance literature:: Multi-step reaction with 5 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: 1,1-dichloroethane / 20 - 70 °C

3: 2,2,6,6-tetramethyl-piperidine-N-oxyl; disodium hydrogenphosphate; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water / 20 - 35 °C

4: pyridine; trifluoro-[1,3,5]triazine / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h

With pyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; N-chloro-succinimide; trifluoro-[1,3,5]triazine; N-ethyl-N,N-diisopropylamine; In 1,1-dichloroethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1236188-83-2
3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride

: 1265750-11-5
tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate

: 429-41-4
tetrabutyl ammonium fluoride

: 1265322-15-3
1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt

Guidance literature:: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride; tert-butyl 1-(2-hydroxy-2-(4-(N'-hydroxycarbamimidoyl)phenyl)ethyl)azetidine-3-carboxylate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 1h;

tetrabutyl ammonium fluoride; In acetonitrile;

With trifluoroacetic acid;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1265322-15-3
1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt

Guidance literature:: Multi-step reaction with 4 steps

1: 1,1-dichloroethane / 20 - 70 °C

2: 2,2,6,6-tetramethyl-piperidine-N-oxyl; disodium hydrogenphosphate; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water / 20 - 35 °C

3: pyridine; trifluoro-[1,3,5]triazine / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h

With pyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; trifluoro-[1,3,5]triazine; N-ethyl-N,N-diisopropylamine; In 1,1-dichloroethane; water; acetonitrile;