3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride

Base Information

• Chemical Name: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride
• CAS No.: 1236188-83-2
• Molecular Formula: C₁₁H₅F₄NO₂
• Molecular Weight: 259.16
• Mol file: 1236188-83-2.mol

Synonyms:3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride

Chemical Property of 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride

There total 5 articles about 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid (1236188-80-9) → 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride (1236188-83-2)

Guidance literature:

With pyridine; trifluoro-[1,3,5]triazine; In dichloromethane; at 20 ℃;

Reference yield: 96.0%

trifluoro-[1,3,5]triazine (675-14-9) + 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid (1236188-80-9) → 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride (1236188-83-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

syn-benzaldehyde oxime (932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2) → 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride (1236188-83-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: 1,1-dichloroethane / 20 - 70 °C

3: 2,2,6,6-tetramethyl-piperidine-N-oxyl; disodium hydrogenphosphate; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water / 20 - 35 °C

4: pyridine; trifluoro-[1,3,5]triazine / 20 °C

With pyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; N-chloro-succinimide; trifluoro-[1,3,5]triazine; In 1,1-dichloroethane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid

phenylhydroxamoyl chloride

syn-benzaldehyde oxime

(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)methanol

Downstream raw materials:

tert-butyl 1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

(2-fluoro-4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

3-(4-iodo-3-methylphenyl)-5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt