N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Base Information

Chemical Name:N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide
CAS No.:1448812-67-6
Molecular Formula:C₂₆H₂₃ClN₆O₂
Molecular Weight:486.961
Hs Code.:

Synonyms:N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

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Chemical Property of N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

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Technology Process of N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

There total 3 articles about N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448812-40-5
N-(5-(((1-(3-bromophenyl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-3-chloro-2-hydroxyphenyl)propionamide

: 1692-15-5
4-pyridylboronic acid

: 1448812-67-6
N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Guidance literature:: With tricalcium phosphate hydrate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 221291-87-8
N-(3-chloro-2-hydroxyphenyl)propionamide

: 1448812-67-6
N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexamethylenetetramine / 130 °C / Inert atmosphere

2.1: toluene / 0.5 h / Reflux

2.2: 0.17 h / Reflux

2.3: 1 h / 0 - 20 °C

3.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; tricalcium phosphate hydrate / water; 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With tricalcium phosphate hydrate; hexamethylenetetramine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; toluene;

Reference yield:

: 1448812-08-5
N-(3-chloro-5-formyl-2-hydroxyphenyl)propionamide

: 1448812-67-6
N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 0.5 h / Reflux

1.2: 0.17 h / Reflux

1.3: 1 h / 0 - 20 °C

2.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; tricalcium phosphate hydrate / water; 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With tricalcium phosphate hydrate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; toluene;