1448812-08-5

Basic information

• Product Name: N-(3-chloro-5-formyl-2-hydroxyphenyl)propionamide
• Synonyms: N-(3-chloro-5-formyl-2-hydroxyphenyl)propionamide
• CAS NO: 1448812-08-5
• Molecular Weight: 227.647
• Mol File: 1448812-08-5.mol

Chemical Properties

• CAS DataBase Reference: N-(3-chloro-5-formyl-2-hydroxyphenyl)propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chloro-5-formyl-2-hydroxyphenyl)propionamide(1448812-08-5)
• EPA Substance Registry System: N-(3-chloro-5-formyl-2-hydroxyphenyl)propionamide(1448812-08-5)

Safety Data

• Hazardous Substances Data: 1448812-08-5(Hazardous Substances Data)

Upstream product

• 221291-87-8 N-(3-chloro-2-hydroxyphenyl)propionamide 
• 64-19-7 acetic acid 
• 603-86-1 2-chloro-6-nitrophenol 

Downstream Products

• 1448812-06-3 N-(3-chloro-5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 
• 1448812-67-6 N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(pyridin-4-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 
• 1448812-68-7 N-(3-chloro-5-(((4-cyano-3-methyl-1-(3-(quinolin-3-yl)phenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 
• 1448812-58-5 N-(3-chloro-5-(((1-(2'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 
• 1448812-61-0 N-(3-chloro-5-(((1-(3'-chloro-[1,1'-biphenyl]-3-yl)-4-cyano-3-methyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 
• 1448812-09-6 N-(2-(benzyloxy)-3-chloro-5-formylphenyl)propionamide 
• 1448812-10-9 C₂₉H₂₅ClN₄O₂ 
• 1448812-05-2 C₂₂H₁₉ClN₄O₂ 
• 1448812-37-0 C₂₂H₂₃ClN₄O₄ 
• 1448812-36-9 N-(3-chloro-5-(((4-cyano-1,3-diphenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 
• 1448812-35-8 N-(3-chloro-5-(((4-cyano-3-ethyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 

Relevant articles and documents

The pyrazole derivative or its salt in a pharmaceutical composition containing them

PROBLEM TO BE SOLVED: To provide a novel compound and a pharmaceutical composition useful for treatment and/or prevention of HIV virus infections.SOLUTION: Provided is a pyrazole derivative represented by the general formula (I) or a salt thereof (in the

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group.